3-Br-UCB-J

Precursor for PET tracer [¹⁸F]UCB-J

Product number: PL-066-P5

Chemical name: (R)-4-(3-Bromo-4,5-difluorophenyl)-1-[(3-methyl-4-pyridyl)methyl]-2-pyrrolidinone

CAS No: NA

M. Weight: 381.21

M. Formula: C17H15BrF2N2O

Purity: >98%

Certificate: CoA, ¹H NMR, ¹³C NMR, HPLC

Application: Neuroscience; Synaptic vesicle glycoprotein 2A (SV2A)

Remarks: Notice to the customers in the US: the 18F labelled derivative of this compound and its use for imaging of synaptic vesicle glycoprotein 2A (SV2A) are covered with an active patent (US11518754B2). Before ordering the precursor please make sure there are no legal restrictions for you to use it. For customers in Europe: according to our knowledge the European patent application (publication number EP3582771) for the same subject is currently pending.

Literature:
Li S, et al. Eur J Nucl Med Mol Imaging. 2019.
Naganawa M, et al. J Nucl Med. 2021.
Sadasivam P, et al. Mol Imaging Biol. 2021.